Benfotiamine capsules

Benfotiamine capsules DEFAULT


Benfotiamine is converted to thiamine, which serves as a key factor for three enzymes involved in generating energy from glucose [1]. Preclinical studies have found that benfotiamine enhances cognitive function and reduces biological markers of Alzheimer's disease [2][3]. These benefits may be due to benfotiamine's ability to suppress the activity of an enzyme that promotes the progression of Alzheimer's [4]. However, benfotiamine's effects on this enzyme have not been confirmed in humans.

At this time, there are no randomized clinical trial data showing that benfotiamine is beneficial for prevention or treatment of age-related cognitive decline or dementia. A phase II clinical trial now underway, however, is testing whether benfotiamine can slow cognitive decline in patients with mild cognitive impairment or Alzheimer's disease [5]. Results have not yet been published.

For Dementia Patients

There is only one small open-label, uncontrolled study which showed that benfotiamine treatment for 18 months resulted in improved cognitive function in Alzheimer's patients [6], though the treatment did not decrease levels of beta-amyloid, a protein common in people with Alzheimer's disease. An ongoing phase II placebo-controlled study, supported in part by the Alzheimer's Drug Discovery Foundation, is testing whether benfotiamine slows cognitive decline in patients with amnestic mild cognitive impairment and Alzheimer's disease [5].


Mega Benfotiamine


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  • 250 mg, 120 vegetarian capsules
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Mega Benfotiamine

250 mg, 120 vegetarian capsules


$0.19/count | 30 - 120 Day Supply

What Is Mega Benfotiamine?

Mega Benfotiamine is formulated with 250 mg of benfotiamine and 10 mg of thiamine (vitamin B1) to support healthy blood sugar metabolism. It also helps protect your body against oxidative stress and glycation, a biochemical reaction that can contribute to a variety of age-related factors.

Benfotiamine can modulate glucose metabolism and support already-healthy blood glucose levels.

Mega Benfotiamine Benefits

  • Helps support healthy blood sugar metabolism
  • Supports already-healthy blood glucose levels
  • Offers protection against advanced glycation end products (AGEs) & oxidative stress

Benfotiamine Better Than Thiamine?

Benfotiamine may also be more helpful in certain situations than thiamine: for example, the enzyme transketolase is critical to blood sugar metabolism and requires thiamine as a cofactor. Unfortunately, the water-soluble thiamine is less available to the interior of the cell, while benfotiamine is fat-soluble and can easily penetrate the cell membrane.

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Benfotiamine, a fat-soluble form of vitamin B1 (thiamine), provides healthy blood sugar metabolism support and helps protect the body’s tissues against advanced glycation end products (AGEs) and oxidative stress.


Benfotiamine is also more bioavailable than the water-soluble thiamine.1 In a landmark study, benfotiamine effectively increased transketolase activity in cell cultures by an astounding 300%, compared to a mere 20% for thiamine. This robust activation was sufficient to block three of the four major metabolic pathways. Benfotiamine also blocked the activation of the transcription factor known as nuclear factor-kappa B (NF-kB). 2

Overall, benfotiamine can modulate glucose metabolism and promote healthy blood glucose levels already within the normal range. By doing so, benfotiamine also helps inhibit the formation of AGEs and supports healthy endothelial function.3


These statements have not been evaluated by the Food and Drug Administration.
These products are not intended to diagnose, treat, cure, or prevent any disease.

  1. Ann Nutr Metab. 1991;35(5):292-296.
  2. Nat Med. 2003;9(3):294-299.
  3. Eur Rev Med Pharmacol Sci. 2018;22(10):3261-3273.

Serving Size 1 vegetarian capsule

Amount Per Serving

Thiamine (vitamin B1) (as thiamine HCl)

10 mg


250 mg

Other ingredients: vegetable cellulose (capsule), microcrystalline cellulose, silica, vegetable stearate, dicalcium phosphate.


Dosage and Use
  • Take one (1) capsule one to four times daily, or as recommended by a healthcare practitioner.


  • Do not purchase if outer seal is broken or damaged.
  • When using nutritional supplements, please consult with your physician if you are undergoing treatment for a medical condition or if you are pregnant or lactating.

To report a serious adverse event or obtain product information, contact 1-866-280-2852.

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What Is Benfotiamine?

Benfotiamine is a dietary supplement that is a derivative of thiamine (also known as vitamin B1), a B vitamin found in a variety of foods including legumes, nuts, seeds, wheat germ, fortified grain products such as bread, cereal, pasta, rice, and flour, and some meat and fish. Since benfotiamine is fat-soluble and appears to have higher bioavailability and better absorption by the body than thiamine, some people use it to raise their thiamine levels and manage certain health conditions.

What Is Benfotiamine Used For?

Thiamine deficiency is considered rare in the United States. With that being said, people who mainly eat highly refined carbohydrates (such as white rice) or unfortified white flour products, or who avoid whole grains, may be at greater risk for a thiamine deficiency. People with prolonged diarrhea, Crohn's disease, and alcohol dependency may also be at risk. Strenuous exercise and conditions like hyperthyroidism increase the body's demand for thiamine, which can lead to a deficiency as well.

Benfotiamine can help restore thiamin levels and help prevent consequences of deficiency, such as nerve, heart, and brain conditions (including a serious condition known as Wernicke's encephalopathy).

In addition, some believe that benfotiamine in supplement form may aid in the treatment of:

Proponents suggest that benfotiamine can shield the body from the harmful effects of advanced glycation end products (AGEs), glycotoxins found in high-fat meats that trigger inflammation and accelerate many aging-related degenerative diseases.

To date, relatively few studies have examined the potential health benefits of taking benfotiamine supplements. Here's a look at some key study findings:


With diabetes, high blood glucose levels can lead to vascular damage through several biochemical pathways, including through the formation of AGEs. This can lead to diabetic neuropathy, a condition characterized by nerve damage.

There is some research to support the idea that benfotiamine may confer protective benefits in this regard. Three of these pathways were found in one animal study to be inhibited by benfotiamine supplementation, indicating it may have a protective effect for people during the progression of this disease.

This effect was supported by another study, published in Diabetes Care in 2006, in which people with type 2 diabetes consumed 1,050 milligrams (mg) of benfotiamine daily and were given a meal high in AGEs before and after the three-day period. Benfotiamine appeared to protect against the oxidative stress induced by these dietary AGEs.

A 2008 double-blind, placebo-controlled, phase III study of over 100 patients found that a medium and high dose of benfotiamine (300 and 600 mg/per day, respectively) led to a non-significant trend toward improved neuropathy symptoms, with the higher dose being more effective.

Despite these promising results, one 12-week study published in PLoS One in 2012 found that benfotiamine didn't significantly affect markers that lead to hyperglycemia-induced vascular complications. Another 2012 study from Diabetes Care, found that 24 months of treatment with benfotiamine had no significant effects on peripheral nerve function or markers of inflammation in participants with type 1 diabetes.

Needless to say, more research is still needed.

Alzheimer's Disease

Amyloid plaques and reduction of glucose metabolism are key features of patients with Alzheimer's disease. According to a 2010 animal study, thiamine-dependent processes that are critical to the metabolism of glucose have been found to be impaired in the brains of Alzheimer's patients, but thiamine supplementation has found to not be effective. Because the body can more easily use benfotiamine than thiamine, and after eight weeks of treatment, reduced amyloid plaque numbers and improved cognitive function were found in the mouse model.

According to a small 2016 clinical study published in Neuroscience Bulletin, five participants with mild to moderate Alzheimer's disease took benfotiamine (300 mg daily) for 18 months. At the study's end, the five participants showed cognitive improvement independent of amyloid plaque accumulation.

These results indicate that benfotiamine may be helpful in the treatment of Alzheimer's disease, however more research is needed for this use as well.

Possible Side Effects

Although little is known about the safety of taking benfotiamine for an extended period of time, there's some concern that benfotiamine supplements may trigger certain side effects such as:

  • Upset stomach
  • Nausea
  • Dizziness
  • Hair loss
  • Weight gain
  • Body odor
  • Decrease in blood pressure

According to a 2017 review, no side effects were reported in clinical trials of thiamine derivatives for a variety of disorders using doses between 300 and 900 mg per day. One study found that nausea and indigestion were reported by several participants when they reached 7,000 and 7,500 mg/day; even though benfotiamine is converted into thiamine in the body, the effects on the body may not be entirely the same.

Benfotiamine is known to contain sulfur and should be avoided by anyone with a sulfur sensitivity.

Keep in mind that the safety of supplements in pregnant women, nursing mothers, children, and those with medical conditions or who are taking medications has not been established.

Dosage and Preparation

According to one study, 320 mg of benfotiamine daily was more effective than 150 mg benfotiamine daily for patients suffering from painful peripheral diabetic neuropathy.

While not many dangerous side effects have been reported, getting up into extremely high doses is not advised as there has not been enough research to date.

Since effective doses have been observed in the 300 mg to 600 mg range for diabetic neuropathy and improved cognitive function in Alzheimer's patients, beginning with a lower dose is a good approach.

If you are considering taking the supplement, speak with your health provider to determine what, if any, amount is right for you.

What to Look For

Widely available for purchase online, benfotiamine supplements can also be found in stores specializing in dietary supplements.

When choosing from one of the available brands, it is a good idea to review the Supplement Facts label on the packaging of the product. This label will contain information about any added fillers, binders, or flavorings, as well as detail the amount of active ingredients per serving.

Look for a product that contains a seal of approval from a third party organization that provides quality testing, such as ConsumerLab. This will assure that the product contains the ingredients as listed without harmful amounts contaminants. A seal of approval from one of these organizations does not guarantee the product's safety or effectiveness, however.

Symptoms of Beriberi (Vitamin B1 Deficiency)

Frequently Asked Questions

  • Doctors may recommend a dose of 150 to 300 mg of benfotiamine twice a day to help decrease diabetic peripheral neuropathy pain. However, more research is needed to determine whether benfotiamine is truly effective.

    Learn More:An Overview of Diabetic Neuropathy

  • Benfotiamine supplements help you to increase your levels of thiamine, also known as vitamin B1. Thiamine is key to a healthy nervous system. Among other possible benefits, some research shows that benfotiamine can help with diabetes-related nerve damage.

Thanks for your feedback!

Verywell Health uses only high-quality sources, including peer-reviewed studies, to support the facts within our articles. Read our editorial process to learn more about how we fact-check and keep our content accurate, reliable, and trustworthy.

  1. Whitfield KC, Bourassa MW, Adamolekun B, et al. Thiamine deficiency disorders: diagnosis, prevalence, and a roadmap for global control programs. Ann N Y Acad Sci. 2018;1430(1):3-43. doi:10.1111/nyas.13919

  2. Hammes HP, Du X, Edelstein D, et al. Benfotiamine blocks three major pathways of hyperglycemic damage and prevents experimental diabetic retinopathy. Nat Med. 2003;9(3):294-9. doi:10.1038/nm834

  3. Stirban A, Negrean M, Stratmann B, et al. Benfotiamine prevents macro- and microvascular endothelial dysfunction and oxidative stress following a meal rich in advanced glycation end products in individuals with type 2 diabetes. Diabetes Care. 2006;29(9):2064-71. doi:10.2337/dc06-0531

  4. Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008;116(10):600-5. doi:10.1055/s-2008-1065351

  5. Alkhalaf A, Kleefstra N, Groenier KH, et al. Effect of benfotiamine on advanced glycation endproducts and markers of endothelial dysfunction and inflammation in diabetic nephropathy. PLoS ONE. 2012;7(7):e40427. doi:10.1371/journal.pone.0040427

  6. Fraser DA, Diep LM, Hovden IA, et al. The effects of long-term oral benfotiamine supplementation on peripheral nerve function and inflammatory markers in patients with type 1 diabetes: a 24-month, double-blind, randomized, placebo-controlled trial. Diabetes Care. 2012;35(5):1095-7. doi:10.2337/dc11-1895

  7. Pan X, Gong N, Zhao J, et al. Powerful beneficial effects of benfotiamine on cognitive impairment and beta-amyloid deposition in amyloid precursor protein/presenilin-1 transgenic mice. Brain. 2010;133(Pt 5):1342-51. doi:10.1093/brain/awq069

  8. Pan X, Chen Z, Fei G, et al. Long-term cognitive improvement after benfotiamine administration in patients with alzheimer's disease. Neurosci Bull. 2016;32(6):591-596. doi:10.1007/s12264-016-0067-0

  9. Meador K, Loring D, Nichols M, et al. Preliminary findings of high-dose thiamine in dementia of Alzheimer's type. J Geriatr Psychiatry Neurol. 1993;6(4):222-9. doi:10.1177/089198879300600408

  10. Winkler G, Pál B, Nagybéganyi E, Ory I, Porochnavec M, Kempler P. Effectiveness of different benfotiamine dosage regimens in the treatment of painful diabetic neuropathy. Arzneimittelforschung. 1999;49(3):220-4. doi:10.1055/s-0031-1300405

  11. Pai ST. Peripheral neuropathy. In: Integrative Medicine. Elsevier; 2018:120-132.e8. doi:10.1016/B978-0-323-35868-2.00013-X

  12. Raj V, Ojha S, Howarth FC, Belur PD, Subramanya SB. Therapeutic potential of benfotiamine and its molecular targets. European Review for Medical and Pharmacological Sciences. 2018;22(10):3261-3273. doi:10.26355/eurrev_201805_15089

Additional Reading
  • Korah, M. C., J. R. Pv, R. Rajeswari, A. Behanan, E. P. Paul, and T. Sivakumar. ADVERSE EFFECTS AND SIDE EFFECTS ON VITAMIN THERAPY: A REVIEW. Asian Journal of Pharmaceutical and Clinical Research. 2017. 10(5).19-26, doi:10.22159/ajpcr.2017.v10i5.17014.

  • Oh SH, Witek RP, Bae SH, Darwiche H, Jung Y, Pi L, Brown A, Petersen BE. Detection of transketolase in bone marrow-derived insulin-producing cells: benfotiamine enhances insulin synthesis and glucose metabolism. Stem Cells Dev. 2009. 18(1):37-46. doi:10.1089/scd.2007.0255.

  • Stracke H, Gaus W, Achenbach U, Federlin K, Bretzel RG. Benfotiamine in diabetic polyneuropathy (BENDIP): results of a randomised, double blind, placebo-controlled clinical study. Exp Clin Endocrinol Diabetes. 2008. 116(10):600-5. doi:10.1055/s-2008-1065351. 

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